Medicinal or Organic Chemists for Small Molecule Drug Discovery

Location
Montréal, Quebec (CA)
Salary
Competitive salary commensurate with experience plus benefits
Posted
Jul 10, 2018
Closes
Sep 08, 2018
Ref
CYC1802
Field of specialization
Medicinal / Clinical, Organic, Pharmaceutical
Job Type
Full time

Research Scientist (Organic or Medicinal Chemistry)

Responsibilities

  • Design and execute synthesis and characterization of small molecule macrocycles, intermediates and building blocks to support internal and collaborative drug discovery and development efforts
  • Assist in the design of molecules and conduct appropriate synthetic follow-up studies to optimize bioactivity obtained in support of internal and collaborative programs
  • Multi-step synthesis (7-12 steps) of new molecules and analogues of lead candidates (milligram to gram scale) individually or in a library format
  • Design and multi-step synthesis (3-5 steps) of fragments to be incorporated into macrocyclic and other molecules (gram to kilogram scale)
  • Purification (flash chromatography, HPLC, crystallization, distillation) and analytical characterization (NMR, IR, LC-MS) of aforementioned molecules and fragments
  • Design and evaluation of alternative synthetic routes for construction of target molecules
  • Design and construction of focused and targeted chemical libraries for screening in selected biological target systems utilizing parallel synthesis techniques
  • Design, synthesis and evaluation of new building block components for macrocyclic molecules and assessment of their suitability for use in library construction as required
  • Development of route optimization strategies and schemes to permit larger scale synthesis of molecules and fragments
  • Design and evaluation of new synthetic processes and improvement of existing procedures to support advanced compound development
  • Acting as a technical resource for other scientific staff members
  • Synthetic procedure preparation and presentation of results internally and externally, including at major scientific conferences
  • Supervision of junior scientific staff members and ensuring that they perform to an expected level
  • Planning work for self and direct reports and completion of tasks on schedule
  • Maintain up-to-date records for all work performed and ensure a safe workplace

Qualifications

  • Ph.D. in Organic or Medicinal Chemistry with a concentration in organic synthesis, including experience with multi-step organic synthesis, with postdoctoral experience is preferred, or M.S. in Chemistry with ten or more years relevant experience
  • Parallel synthesis and/or solid phase synthetic experience are considered a plus
  • Ability to work in a dynamic, fast-paced environment, flexibility
  • Proven track record of scientific achievement, as demonstrated by successful R & D accomplishments and peer-reviewed publications
  • Dedication, attention to detail, ability to work in an interdependent team
  • Excellent oral and written communication skills
  • Very good computer proficiency including standard office programs, electronic lab notebooks, use of chemical structure drawing programs, presentation preparation and database searching