NYU Langone Medical Center, a world-class, patient-centered, integrated, academic medical center, is one of the nation's premier centers for excellence in clinical care, biomedical research and medical education. Located in the heart of Manhattan, NYU Langone is composed of four hospitals - Tisch Hospital, its flagship acute care facility; Rusk Rehabilitation; the Hospital for Joint Diseases, one of only five hospitals in the nation dedicated to orthopaedics and rheumatology; and Hassenfeld Children's Hospital, a comprehensive pediatric hospital supporting a full array of children's health services across the medical center - plus the NYU School of Medicine, which since 1841 has trained thousands of physicians and scientists who have helped to shape the course of medical history. The medical center's tri-fold mission to serve, teach and discover is achieved 365 days a year through the seamless integration of a culture devoted to excellence in patient care, education and research. For more information, go to www.NYULMC.org.
We have an exciting opportunity to join our team as a Associate Research Technician.
In this role under the supervision of Christopher William, M.D., Ph.D., in the Department of Pathology, the technician will conduct a variety of standard molecular biological and histological methods, acquire significant knowledge in the fields of neurodegenerative disease and postnatal mouse visual system development and gain experience in molecular biology, protein biochemistry, microscopic and histologic techniques and the study of disease processes in animal models. The research includes microsurgery on the mouse eye and eye lid, cranial surgery and in vivo imaging in awake mice. The technician will learn to independently design, plan and carry out studies. The research effort is focused on improving our understanding of the pathologic processes underlying neurodegeneration in Alzheimers disease and neurodevelopmental impairment in Down syndrome, primarily by exploring the roles that synaptic plasticity and synaptic dysfunction play in both disease processes. In the developing mouse visual system, activity-dependent competition and synaptic plasticity shape the wiring of responses in the visual cortex to sensory input from left and right eyes. This process can be challenged by closure of one eye for 4-6 days, a process that causes the brain to rewire in favor of the non-deprived eye. Mouse models of Alzheimers disease and of Down syndrome exhibit defects in this basic plastic response, suggesting that this system can be used to better understand circuit dysfunction in both diseases. An additional goal of these studies is to develop an approach in which potential therapies can be tested for their ability to rescue synaptic function in the context of the intact, functioning, mouse model brain. Human tissue from disease and control brains may also be studied to complement and test hypotheses driven by animal model work in these projects.
- DNA related techniques: preparation of plasmids, gel electrophoresis, cloning of vector constructs
- Histologic studies: routine histologic stains, immunohistochemistry, in situ hybridization
- Mouse husbandry, assistance in maintenance of a mouse colony and performance of microsurgery including, but not limited to eye lid suture, eye enucleation and cranial window placement
- Protein chemistry: protein expression, protein quantification, Western blotting, co-immunoprecipitation studies and pulldown experiments
- Procurement of supplies, the scientific maintenance of the laboratory and the organization of research material
- Image analysis with computer programs, data management, laboratory notebook maintenance
- Library research and database analysis, preparation of manuscripts, upkeep of written records, of experimental procedures and data analysis
- Instruct students and others in molecular biology methodology and laboratory instrument operation and participate and present data at lab meetings
To qualify you must have a A Bachelor's of Science Degree in Life Sciences or a related field is preferred. Experience in laboratory specific organization of processes, operation and maintenance of equipment, and documentation of performed experiments. Strong written and verbal communication skills are required. Must be able to multi-task and work independently.
Qualified candidates must be able to effectively communicate with all levels of the organization.
NYU Langone Medical Center provides its staff with far more than just a place to work. Rather, we are an institution you can be proud of, an institution where you'll feel good about devoting your time and your talents. And just as our employees invest so much in us, we invest in our employees. We're pleased to have one of the most competitive compensation packages not only among New York's hospitals and healthcare institutions, but within the corporate sector as well. We begin with exceptional medical, dental, and drug coverage. We enhance this basic coverage with comprehensive wellness programs, and supplement those with retirement investment and benefits plans, and generous paid time off allowances. Add to that a very attractive tuition program, and you'll see just some of the ways that NYU Langone Medical Center demonstrates our commitment to our employees.
NYU Langone Medical Center is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, military and veteran status, genetic information or any other factor which cannot lawfully be used as a basis for an employment decision.
We require applications to be completed online.
If you wish to view NYU Langone Medical Center's EEO policies, please click here. Please click here to view the Federal 'EEO is the law' poster or visit http://www1.eeoc.gov/employers/poster.cfm for more information.