Medicinal Chemists

The NIH Chemical Genomic Center (NCGC) is looking for Research Scientists for our Rockville, Maryland location with expertise in organic synthesis and medicinal chemistry. NGCG is one of the branches of the National Center for Advancing Translational Sciences (NCATS). Part of our mission is the development of new therapeutic approaches in areas of medical need. For doing so, we partner with external collaborators specialized in specific disorders creating a multidisciplinary team with expertise in assay development and High-throughput screening (HTS), bioinformatics analysis, medicinal chemistry and disease-relevant biological models. Our aim is to produce small molecule probes able to validate new therapeutic approaches to cure or ameliorate diseases. 

The selected Research Scientists will work in a highly creative environment synthesizing and optimizing potential probes molecules and preclinical candidates directed towards the discovery of new medicines to treat diseases. Their job will involve synthesize, purify, identify, characterize and analyze (NMR, IR, MS) compounds under the supervision of a chemistry team leader. The ideal candidate should be independent and well trained in the field of medicinal chemistry and will be responsible for conducting research, move forward and advance specific programs in coordination with the team leader. Understanding and previous experience in SAR studies and pharmacokinetic optimization/ evaluation is highly desirable. Keep accurate and complete records of all scientific experiments according to established procedures, and ensure that these records and raw data are properly retained. Draft technical reports, manuscripts and patent applications and maintain experimental data together with the use of statistical packages and standard databases. Present work internally and to external consultants and collaborators as needed.

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Position requires a Ph.D. degree in Chemistry with one to ten years of experience in pharmaceutical industry or related position. Exceptional candidates in post-doctoral training will be also considered. Alternatively Master’s degree candidates with extensive experience are also encouraged to apply. Experience in drug development and optimization is highly desirable. The candidate should be an independent thinker and team player able to work in a very interactive high pace environment, well trained in methods and concepts of medicinal chemistry.  Experience is required in proposing and reducing to practice multi-step syntheses as well as experience in standard spectroscopic and purification methods, including NMR (routine pulse techniques for structure determination), and standard automated liquid chromatography and HPLC methods.