Principal/Senior Principal Scientist Medicinal Chemistry

Company Overview


UCB, is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.2 billion in 2016.  UCB invests more than 25% of revenue in cutting-edge scientific research to with the objective of solving unmet patient needs.  We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases. At UCB everything we do starts with a simple question: "How will this make a difference to the lives of people living with severe diseases?" We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.


Role Overview


We are seeking world class scientific leaders to help us advance our small molecule drug discovery projects to critical decision making milestones, from target validation to pre-clinical candidate selection and beyond.  The key responsibilities are:

        Driving medicinal chemistry strategy and delivery of project milestones in NCE discovery

        Building upon medicinal chemistry functional excellence

        Fostering innovation, forging strong internal and external cross-functional collaborations, and scientific cross-fertilisation of the laboratories beyond the immediate area of project responsibility

        Developing drug discovery capabilities, establishing and monitoring external collaborations,

        Providing support for in- and out-licensing activity and contributing to a strong portfolio of novel therapeutic targets and projects.  


Candidate Requirements


The successful candidate will have a demonstrated track record of scientific leadership and delivery, as evidenced by contributions to development candidates. In addition, applicants should be creative problem solvers who exhibit sound scientific judgement, coupled with proven efficient delivery of medicinal chemistry programs.   The ideal candidate will create an effective working relationship in a matrix environment and may be expected to participate in local functional management including hiring and mentoring of staff.  Excellent communication skills are essential along with an established record of high quality publications, presentations and patents. The candidate will be expected to serve as an ambassador for UCB in the broader scientific community. 


The candidate should have a BSc/MSc/PhD in organic chemistry with appropriate industrial experience and be a recognised expert in medicinal chemistry.  Sound knowledge of computational chemistry, chemoinformatics, drug metabolism and pharmacokinetics (DMPK) and biology are essential. A detailed understanding of, and commitment to, novel enabling technologies and ways to advance medicinal chemistry as a discipline and to achieve high productivity would be beneficial. This position will be based at our UK (Slough) or BE (Braine l’Alleud) laboratories.


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