Senior Scientist - Vaccine Process Development

West Point, Pennsylvania
Commensurate with experience
Aug 31, 2017
Sep 30, 2017
Field of specialization
Work Function
Job Type
Full time

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Senior Scientist - Vaccine Process Development
West Point, PA
Job # BIO004909


Applicants are sought for Vaccine Process Development group in Vaccine Bioprocess Research and Development of Merck Research Labs. The VPD group develops processes consisting of multiple unit operations for the production of vaccine candidates. Processes are initially developed in the laboratory and are then scaled up to pilot and full-manufacturing scales. Significant amount of laboratory work are conducted to understand how processing variables impact product quality attributes at each step of the process at all operating scales. Candidate will serve as an individual scientific contributor responsible for designing and executing experiments and analyzing results from studies. Candidate will also be involved in technology transfers to pilot and manufacturing groups.

The successful candidate will have a background in biological science or bio/chemical engineering and strong expertise in hands-on, laboratory work. Experience in protein and polysaccharide purification using techniques, such as ultrafiltration, chromatography, dead-end filtration and centrifugation, is required. Experience in bioconjugation and analytical methods, such as HPLC, will be considered as a strong positive factor. To support technology transfers, experience in cGMP practices is also desired. The candidate should be self-motivated, independent, well-organized, have strong problem-solving skills, and be able to think strategically.

The candidate must be able to work well with others. The individual will be expected to demonstrate the ability to communicate results of his/her work in both verbal and written formats. In addition to the core responsibilities outlined above, the candidate will be expected to keep careful notes, comply with all required training, and maintain a focused attention on laboratory safety.




  • BS degree in Chemical Engineering or Biological Sciences with a minimum of 7 years of relevant experience OR MS degree in Chemical Engineering or Biological Science with a minimum of 4 years of relevant experience OR PhD in Chemical Engineering or Biological Sciences with technical background in downstream (purification) process development of biological molecule.


  • Experience in preparative purification of proteins, viruses, VLPs, and/or other biological molecules. Strong laboratory skill set, with experience designing and executing experiments independently in a manner that meets quality and time line expectations.
  • Advanced proficiency in chromatography, membrane filtration operations, and common biochemical analytical techniques.
  • Ability to understand and execute experiments independently in fulfillment of assigned program objectives in a manner that meets quality and time line expectations
  • Well-developed organizational, record-keeping, and problem solving skills
  • Ability to work independently and/or in a team environment and is results oriented


  • Downstream process development experience for vaccine candidates and/or therapeutic proteins, including experience in process operations scale-up.
  • Experience in the purification of live viruses and familiarity with established safety practices for working with such organisms including hands-on experience with Biosafety Level 2 operations
  • Experience in programming (e.g. Visual Basic, CC+, MatLab) and statistical/visualization software.
  • Communication of scientific information through oral presentations and written documents.
  • Conflict management and negotiation skills
  • Extensive experience with GxP principles and regulations.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

To be considered for this position, please visit our career site at, search jobs, create a profile and submit your resume for requisition # BIO004909 to:

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