Scientist, Chemistry

Location
Jupiter, Florida
Salary
Competitive Package
Posted
Dec 20, 2018
Closes
Jan 19, 2019
Field of specialization
Pharmaceutical
Work Function
Research-Applied
Job Type
Full time

Expansion Therapeutics is a drug discovery and development company pursuing the vast potential of

small molecule medicines for RNA‐mediated diseases. We are initially focused on expansion repeat

disorders, a set of ~30 genetic diseases for which there are no satisfactory therapies. Our lead disease

focus, myotonic dystrophy type 1 (DM1), is the most frequent cause of adult onset muscular dystrophy.

Expansion has assembled an initial focused pipeline of compositions targeting repeats that drive a

number of expansion repeat disorders.

Summary

Perform research in the laboratory as a synthetic and medicinal chemist applying the latest knowledge and techniques in the field. Advance the assigned program and contribute to the identification of a lead or development candidate.

Essential Functions

• Design and execute syntheses of complex organic molecules on a milligram to multi-gram scale

• Use advanced laboratory techniques to purify mixtures of compounds

• Use state of the art techniques to characterize intermediates and final compounds

• Rationally design a series of target molecules for a pharmacological target of interest

• Use medicinal chemistry tools and techniques to plan and design synthetic targets

• Communicate results to co-workers and management in both oral and written manner and assist in the preparation of patent applications

Qualifications

• Ph.D. in synthetic organic chemistry strongly preferred; a combination of relevant education and applicable job experience may be considered

• 1-2 years of post-graduate experience working in the biotechnology or pharmaceutical industry or a related position as a laboratory scientist

• Highly proficient in advanced synthetic, purification and spectroscopic techniques utilized in the preparation and characterization of complex organic molecules

• Demonstrated ability to design synthetic targets and successfully execute their syntheses

• Several first author or co-author publications in peer-reviewed journals demonstrating research accomplishments is preferred

• Familiarity with Structure-Based Drug Design

• Firm understanding of modern Medicinal Chemistry concepts and the ability to use them in the design of target molecules or to improve the properties of existing compounds

• Ability to work effectively in teams and collaborate with other scientists including microbiologists, structural biologists, pharmacologists and toxicologists

• Self-starter with a strong work ethic and ability to work independently and show flexibility when needed

• Effective oral and written English communication skills

• Familiarity with standard laboratory instrumentation, computers, and office and laboratory software