Research Chemist II

Cambridge, Massachusetts
Compensation commensurate with experience
May 21, 2019
Jun 20, 2019
Job Type
Full time

 The Broad Institute’s Center for the Development of Therapeutics (CDoT) is a unique place for drug discovery – our mission is to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. CDoT is a team of professional “drug hunters” who collaborate with faculty at MIT, Harvard and the Harvard teaching hospitals to translate emerging biological insights into novel therapeutic strategies. We couple novel technologies and approaches to industry-standard drug discovery rigor to tackle some of the most challenging targets across a wide range of disease areas (including oncology, cardiovascular disease, diabetes, psychiatric disease and infectious disease).

We are looking for a highly motivated scientist to join a team of medicinal and computational chemists focused on discovering novel small molecule therapeutics for psychiatric diseases. The successful candidate will join The Center for the Development of Therapeutics and lead therapeutic projects from the Stanley Center for psychiatric Research. The candidate will work closely with neuroscientists, biochemists, structural and biophysical scientists, cell biologists and pharmacologists, to rapidly progress therapeutic projects in partnership with academic scientists and industrial partners. The successful applicant will have the unique opportunity to influence both the strategy and execution of multiple therapeutic programs driven by the novel genetic and biological insights being discovered at the Broad Institute.


•         PhD with 5+ years of research experience in an industrial setting managing a team of professional chemists, including contract research chemists.

•         Must have a track-record of success in moving drug discovery programs efficiently from screening through to development or clinical candidates as project team leader.

•         Must have deep experience leading multi-disciplinary teams and utilizing cross-functional data to drive drug discovery strategies in a matrix organization environment.

•         Experience mentoring and managing highly skilled scientific staff through different career stages

•         Demonstrated leadership by implementing medicinal chemistry strategies across all stages of drug discovery from hit identification, through lead optimization to clinical candidate selection.

•         Significant experience in cutting-edge synthetic chemistry, with evidence of creative solutions to complex synthesis problems.

•         Experience managing and integrating internal resources with external commercial collaborators and contract research organizations to achieve project goals in a timely and cost effective manner.

•         Experience in psychiatric research drug discovery is a plus.

•         Must have strong interpersonal and communication skills.

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