Post Doctoral Metabolism/Residue Chemist
Description: A Post-Doctoral research associate position is available at the Animal Metabolism-Agricultural Chemicals Research Unit, Edward T. Schafer Agricultural Research Center, in Fargo, ND. The mission of the Unit is to investigate the fate of agricultural chemicals and environmental pollutants in food animals and food animal systems. Research responsibilities will include 1) executing studies on the absorption, distribution, metabolism, and excretion (ADME) of halogenated persistent organic pollutants (POPs; e.g., brominated flame retardants, halogenated dioxins, perfluorinated compounds, etc.) in animals used for human food (for example, sheep, goats, cattle, poultry, swine, and/or rabbits); 2) the synthesis and/or analysis of test compounds with the incorporation of heavy- or radiolabeled isotopes to support ADME studies.
The goal of the project is to completely describe the distribution and metabolic fate of target molecules in relevant food animal species and their primary food products (milk, meat, and/or eggs). To this end, the successful candidate will conduct ADME studies in food animals dosed with radiolabeled target molecules. Specifically, radiolabeled POPs will be prepared and/or purified in sufficient quantity for oral dosing to lactating dairy goats or to laying hens. After dosing, blood samples will be taken at regular intervals to measure systemic rates of radiocarbon appearance and depletion. The total mass balance of radioactivity in tissues, urine, feces, and milk or eggs will be determined. The identities of extractable metabolites present in excreta, tissues, milk and/or eggs will elucidated by physical means (NMR, mass spectrometry) following chromatographic purification.
Requirements: A Ph.D. in organic chemistry, biochemistry, pharmacology, toxicology, animal sciences or a related field is required. The research assignment requires professional knowledge of synthetic organic chemistry, biochemistry, spectroscopies (NMR, UV/Visible, fluorescence, etc.), mass spectrometry, chromatography (gas, liquid, and thin layer), and laboratory safety (especially with regards to potentially toxic POPs and use of radioisotopes). The assignment also requires working knowledge of the principles of drug metabolism, pharmacology, and(or) toxicology. A willingness to work directly with food animals (cattle, goats, sheep, poultry, and/or swine) and food animal tissues and/or excreta is a requirement.
Interested candidates who are US citizens or who hold a permanent resident card ("green card") are encouraged to apply by providing a resume, academic transcripts, and three references.
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