Principal Research Scientist / Team Lead, Protein Degradation - Medicinal Chemistry

Employer
Kronos Bio
Location
Cambridge, Massachusetts
Salary
DOE
Posted
Sep 04, 2019
Closes
Oct 04, 2019
Field of specialization
Biological, Medicinal / Clinical, Pharmaceutical
Job Type
Full time

 

Principal Research Scientist / Team Lead, Protein Degradation - Medicinal Chemistry

Location: Cambridge, MA

 

Kronos Bio, an early-stage pharmaceutical company located in Cambridge, MA, seeks a creative, enthusiastic, and results-oriented individual to join its chemistry team at the Principal Scientist level. As a member of the discovery/medicinal chemistry team, this individual will be responsible for independently developing and implementing medicinal chemistry strategies that effectively surmount complex research problems and facilitate the achievement of key corporate goals – on time and on budget. This individual will act as chemistry project leader for one or more new projects and manage a team of CRO-based chemists, while maintaining close interactions with computer-assisted design scientists, biologists, pharmacologists, and pharmaceutical development scientists. The applicant is expected to have strong experimental skills, good communication ability, eagerness for learning, and contribute to a strong culture of teamwork and collaboration.

Principal Duties and Responsibilities:

  • Requires the expeditious molecular and synthetic design of PROTACs/Targeted Protein Degrader
  • Communicate project updates to management team, internal colleagues, and external collaborators
  • Coordinate project activities with other disciplines including structural biology, target compound profiling, biology, and pharmacology
  • Contribute to the overall strategy and creation of intellectual property documentation
  • Seize opportunities to pursue project relevant leads that are in line with the group's strategy and contribute new ideas to the project team.
  • Act as technical resource in a defined area, and be willing to perform tasks outside applicant’s area of expertise
  • Be able to interpret relevant ADME, PK, and other biochemical assays to accelerate drug development efforts
  • Design, implement, and execute medicinal chemistry strategy with a team of CRO-based medicinal chemists in the synthesis of analogues and key intermediates, including:
  • Ensuring quality of work and data generated
  • Understanding CRO capabilities, and troubleshooting synthetic schemes as needed to accelerate analogue delivery
  • Identify key challenges in medicinal chemistry routes, and devise alternate routes to enable scalability and safety in the delivery of pre-clinical lots
  • Managing priorities and timelines for deliverables
  • Facilitating communications between chemists and serving as the primary point of contact with the CRO
  • Occasional laboratory work is encouraged to resolve outstanding synthetic issues, or to assist in the continued development of Kronos Bio’s core technology platform.

 

 

Job qualifications: 

  • PhD with 5+ years industry experience in pharmaceutical hit-to-lead optimization, including at least 2 years of experience managing external / CRO driven medicinal chemistry campaigns.
  • Strong track record of scientific innovation, and understanding of pre-clinical discovery process
  • In-depth knowledge of ADME/PK assays and their interpretation towards optimizing high-quality drug candidates
  • Expertise in database searching (SciFinder, Reaxys) and modern synthetic methods.
  • Clearly demonstrates effective organizational, communication, interpersonal, and managerial skills
  • Experience with programs involving phenotypic screens, “undruggable” targets, or selective protein degradation is a plus
  • Show initiative to expand scope and depth of technical competence.
  • Independence in planning work to support the team, project objectives, and corporate priorities.
  • Work together with other members of a project team to accomplish team objectives.
  • Demonstrate resiliency and flexibility when confronted with programmatic changes and/or new scientific directions.

Interested candidates should forward a resume and cover letter to careers@kronosbio.com.

Kronos Bio, Inc., is dedicated to the research and development of first-in-class therapies that modulate historically “undruggable” cancer targets. Leveraging industry-leading research into high-throughput screening strategies for chemical modulators of transcription factors and other challenging targets in oncology, Kronos Bio utilizes its small molecule microarray (SMM) platform and extensive know-how in biological assay development to pursue novel therapies against some of the most important and intractable targets in cancer research

Apply for Principal Research Scientist / Team Lead, Protein Degradation - Medicinal Chemistry

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from C&ENJobs by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on C&ENJobs you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs