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Process Chemist

Employer
The National Institutes of Health
Location
Bethesda, Maryland
Salary
Salary is commensurate with research experience and accomplishments.
Closing date
Nov 9, 2019

Department of Health and Human Services

National Institutes of Health

National Heart, Lung, and Blood Institute

Process Chemist

With nation-wide responsibility for improving the health and well-being of all Americans, the Department of Health and Human Services oversees the biomedical research programs of the National Institutes of Health and those of NIH’s research Institutes.

The National Heart, Lung, and Blood Institute (NHLBI) is looking for an experienced synthetic organic chemist to work within the Imaging Probe Development Center (IPDC).  The Imaging Probe Development Center of the NIH is a core facility to supply otherwise unavailable molecular imaging probes or early drug discovery compounds to collaborating scientists.  Candidates must have an MS/MA with at least 5 years of industrial experience, or PhD with at least two years of post-doctoral research, in organic synthesis or medicinal chemistry.  The ideal candidate will have expertise in process chemistry and reaction optimization (up to 100g scale).  Experience with continuous flow based reaction systems or supercritical CO2 equipment would be useful.  Knowledge of modern synthetic techniques and expertise in common analytical methods are expected. 

The chemist will scale-up synthesis of intermediates or final compounds.  The small molecules are for diagnostic imaging applications, or early drug discovery efforts.  Adapting known reaction sequences to continuous flow based operations is also possible.  The ability to propose engineering solutions to automated compound preparation using air and water sensitive reagents is helpful.  The work will require the ability to devise synthetic approaches to target molecules and propose alternative synthetic routes.  The candidate should have good communication skills and be able to work in a collaborative environment, within a service group.

Salary is commensurate with research experience and accomplishments.

Applicants should submit their current curriculum vitae with complete bibliography to Dr. Rolf Swenson at nhlbi_ipdc@nhlbi.nih.gov.

HHS and NIH are Equal Opportunity Employers

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