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Postdoctoral Researcher

Employer
University of Pennsylvania School of Medicine
Location
Philadelphia, Pennsylvania
Salary
$55,000 + health insurance
Closing date
Apr 24, 2020

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Field of specialization
Biochemical
Work Function
Laboratory
Job Type
Full time

Job Details

Air-pollution is ranked as a Group 1 carcinogen by the International Agency for Research on Cancer. Nitroarenes are among the carcinogens responsible, however, the nitroreductases involved in their metabolic activation have not been fully identified. A postdoctoral position is available immediately to study the role of the nitroreductase activity of human aldo-keto reductases (AKRs) in the metabolic activation of nitroarenes. Studies involve measurement of DNA-adducts in bronchial epithelial cells with genetic and pharmacological manipulation of AKRs; induction of AKRs by the Nrf2-Keap1 pathway and determination of whether this exacerbates nitroarene activation; and examination of single-nucleotide polymorphisms in AKR genes and their impact on nitroreductase activity. The position is available in the laboratory of Trevor M. Penning in the Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania.  A successful applicant can participate in a rigorous training program supported by training faculty in basic and clinical sciences.

Required qualifications: PhD within the last three years in the biomedical sciences (e.g. biochemistry, pharmacology, toxicology, or analytical chemistry).

Preferred qualifications: Strong background in enzymology, analytical chemistry using LC-MS/MS, mammalian cell culture, gene and protein expression (western blot analysis, real-time PCR, enzyme assays); use of si-RNA, sh-RNA and CRISPR/cas9 is desirable.

For consideration please email: penning@upenn.edu, a cover letter, curriculum vitae and list of three references.

For more information on the Penning laboratory visit:

https://www.med.upenn.edu/apps/faculty/index.php/g275/p12620

For more information on the Center of Excellence in Environmental Toxicology visit:

http://ceet.upenn.edu/

Company

The University of Pennsylvania School of Medicine is one of 12 professional schools of the University located in Philadelphia. It trains 850 postdoctoral scientists in research laboratories and has comprehensive policies on postdoctoral appointments, compensation and benefits. The umbrella organization responsible for postdoctoral appointments and training Is Biomedical Postdoctoral Programs (BPP) visit www.med.upenn.edu/postdoc. BPP also provides professional skills training and career development programs. The School of Medicine is routinely ranked 2nd or 3rd in NIH grants awarded.

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