Medicinal or Organic Chemists for Small Molecule Drug Discovery

Research Scientist (Organic or Medicinal Chemistry)

Responsibilities

• Design and execute synthesis and characterization of small molecule macrocycles, intermediates and building blocks to support internal and collaborative drug discovery and development efforts
• Assist in the design of molecules and conduct appropriate synthetic follow-up studies to optimize bioactivity obtained in support of internal and collaborative programs
• Multi-step synthesis (7-12 steps) of new molecules and analogues of lead candidates (milligram to gram scale) individually or in a library format
• Design and multi-step synthesis (3-5 steps) of fragments to be incorporated into macrocyclic and other molecules (gram to kilogram scale)
• Purification (flash chromatography, HPLC, crystallization, distillation) and analytical characterization (NMR, IR, LC-MS) of aforementioned molecules and fragments
• Design and evaluation of alternative synthetic routes for construction of target molecules
• Design and construction of focused and targeted chemical libraries for screening in selected biological target systems utilizing parallel synthesis techniques
• Design, synthesis and evaluation of new building block components for macrocyclic molecules and assessment of their suitability for use in library construction as required
• Development of route optimization strategies and schemes to permit larger scale synthesis of molecules and fragments
• Design and evaluation of new synthetic processes and improvement of existing procedures to support advanced compound development
• Acting as a technical resource for other scientific staff members
• Synthetic procedure preparation and presentation of results internally and externally, including at major scientific conferences
• Supervision of junior scientific staff members and ensuring that they perform to an expected level
• Planning work for self and direct reports and completion of tasks on schedule
• Maintain up-to-date records for all work performed and ensure a safe workplace

Qualifications

• Ph.D. in Organic or Medicinal Chemistry with a concentration in organic synthesis, including experience with multi-step organic synthesis, with industry experience preferred, or M.S. in Chemistry with five or more years relevant experience
• Parallel synthesis and/or solid phase synthetic experience are considered a plus
• Ability to work in a dynamic, fast-paced environment, flexibility
• Proven track record of scientific achievement, as demonstrated by successful R & D accomplishments and peer-reviewed publications
• Dedication, attention to detail, ability to work in an interdependent team
• Excellent oral and written communication skills
• Very good computer proficiency including standard office programs, electronic lab notebooks, use of chemical structure drawing programs, presentation preparation and database searching