Scientist - Small Molecule Process Chemistry, Genentech Research

Location
94080, South San Francisco
Salary
DOE
Posted
Oct 01, 2020
Closes
Nov 30, 2020
Field of specialization
Biochemical
Job Type
Full time

Join a Team that Lives to Improve Lives
People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen. 

The following opportunity exists in our South San Francisco, CA headquarters:

Scientist - Small Molecule Process Chemistry, Genentech Research

Description

Genentech is seeking a top-tier Chemistry Scientist with a proven record of sustained laboratory achievement and innovation to join our Small Molecule Process Chemistry group. The Scientist, leading from the bench as part of our project-based research and development staff, is responsible for:

  • Developing enabling chemistry during early and/or late stage research in support of early development-readiness decisions
  • Developing processes to manufacture Active Pharmaceutical Ingredient (API) in early development through Phase III route selection
  • Delivering API supply in early phase clinical development

Using the enabling chemistry developed, the Scientist, working with our South San Francisco clinical manufacturing team, will participate in the production of early phase GMP clinical supplies. Eventual route selection for late stage GMP API manufacturing is also the responsibility of the Scientist and includes the concepts of safe, efficient, robust, environmentally sound chemistry and extends to the synthesis of the regulatory starting materials and establishment of a robust supply chain. A key job requirement is the ability to interact closely with discovery chemists and sourcing partners throughout development. The Scientist is expected to maintain a high-level scientific profile both internally and externally in terms of scholarly achievements and pipeline contributions.

The successful candidate will be responsible for developing processes suitable for controlling the quality of bulk API as required by cGMP, ICH and FDA regulations as well as the bulk attributes conducive to successful formulation development. In addition, writing relevant CMC sections of INDs and participating in developing a strategy for quality are important tasks. The position's mission will be accomplished through innovation and teamwork, collaboration with strategic partners, creative problem solving and use of state-of-the-art technology.

Who You Are

Successful candidates will possess the following qualifications:

  • PhD in relevant scientific discipline with 0-3 years industry experience
  • Outstanding record of innovation and success in multiple projects over the course of their graduate, post-doctoral and industrial career with a sustained publication record
  • Strong working knowledge of the latest developments in contemporary Process
  • Chemistry including chemo- and bio-catalysis, organometallic chemistry as well as expertise in asymmetric transformations, heterocyclic chemistry, and/or peptide chemistry
  • Demonstrated experience at the kilogram delivery scale is preferred
  • Ability to interact, learn and eventually lead in a CMC/cross functional environment
  • Ability to take initiative, provide strategic input, problem solve, work in teams, develop people and communicate clearly, both orally and in writing

Applicants should plan to submit a short Research Summary in addition to their CV.


Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and
life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. 

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.
 

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