Scientist, Drug Metabolism and Pharmacokinetics - Bioanalysis

Location
94080, South San Francisco
Salary
DOE
Posted
May 20, 2021
Closes
Jul 19, 2021
Field of specialization
Analytical, Biochemical
Work Function
Laboratory
Job Type
Full time

Join a Team that Lives to Improve Lives
People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen. 

The following opportunity exists in our South San Francisco, CA headquarters:

Scientist, Drug Metabolism and Pharmacokinetics - Bioanalysis

Description
The Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech is seeking a highly motivated Associate Scientist to join the Bioanalytical (BA) function.  The DMPK-BA function is primarily responsible for overseeing regulated bioanalytical activities conducted at contract research laboratories (CROs), and ensuring overall compliance with GLP/GCP regulations to support the preclinical and clinical development of Genentech’s small molecule programs.

Responsibilities include, but are not limited to:

  • Technical monitoring during bioanalytical method development, validation, and sample analysis; overseeing method transfer between CROs
  • Reviewing validation reports and experimental documentation; and archiving relevant study documents.
  • Conducting CRO evaluation and selection,
  • Reviewing CRO SOPs
  • Determine additional bioanalytical requirements if needed, and perform regular site visits and inspection.
  • Internally, the individuals are responsible for developing highly sensitive and specific bioanalytical methods for quantitative analysis of new chemical entities, metabolites, and biomarkers in a variety of biological matrices, reproducing CRO-developed methods, and performing non-regulated quantitative bioanalysis.
  • The individuals serve as bioanalytical representatives on interdisciplinary project teams. In addition, the individuals may supervise and train junior staff to successfully perform all the above-mentioned responsibilities.

Who You Are
Qualifications:

  • Doctoral degree in analytical chemistry, biochemistry, or equivalent with relevant industry experience of 0 to 3 years.
  • Demonstrated ability to work independently in a fast-paced environment, as well as in a team setting.
  • In-depth bioanalytical knowledge and extensive experience with modern analytical instrument platforms, particularly with LC-MS/MS.
  • Hands-on experience in developing and validating LC-MS bioanalytical methods using various techniques (SLE, LLE, SPE, and PP),
  • Strong ability to manage multiple studies simultaneously and be able to assist in troubleshooting when instrument or assay problems arise.
  • Good understanding of GLP/GCP regulations
  • Possess excellent oral and written communication skills.
  • Prior working experience at or with CROs is preferred.

Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and
life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. 

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.