Assistant / Associate / Senior Research Professor of Medicine - Clinical Pharmacology

7 days left

Location
Indianapolis, Indiana
Salary
DOE
Posted
Jul 13, 2021
Closes
Aug 12, 2021
Field of specialization
Medicinal / Clinical
Work Function
Research-Basic
Job Type
Full time

Assistant/Associate/Senior Research Professor of Medicine - Clinical Pharmacology

Indiana University School of Medicine

Position Summary

The Department of Medicine, Division of Clinical Pharmacology at the Indiana University School of Medicine is seeking a highly motivated, passionate, and proactive individual to perform early drug discovery research within a dynamic and innovative academic setting. The IUSM-Purdue TREAT-AD Center was established to generate high-quality lead molecules against novel biological targets for the treatment of Alzheimer’s Disease. The Medicinal Chemistry and Chemical Biology (MCCB) Core was established as a nexus point of the Center to achieve our primary objective of designing high-quality lead molecules suitable for further optimization into drug candidates. The MCCB Core complements deep biology expertise within the Stark Neurosciences Research Institute and the capabilities of the Indiana Clinical and Translational Sciences Institute (CTSI). The successful candidate will also have opportunities to collaborate with researchers in IU Simon Comprehensive Cancer Center and the Indiana Biosciences Research Institute (IBRI). Given the academic, biotech-like nature of our goals, the cultural fit of a successful candidate is an important criterion for success. Desired characteristics include a “can do” attitude, a high level of curiosity and self-motivation, and the ability to work independently and collaboratively with others.

 

The responsibilities of this candidate will be to perform research-related activities including analyzing data, writing grants, and drafting manuscripts. In this career path your primary responsibilities, both independently and in collaboration with other scientists, will be to evaluate promising biological targets, develop strategies to synthesize small molecule ligands for these targets, review physicochemical and biological data, and optimize leads for sufficient target engagement in vivo. You will also be responsible for establishing medicinal chemistry labs within the IU School of Medicine’s Biotechnology Research & Training Center (BRTC) on the near-west side of Indianapolis. The labs, along with supporting facilities, include a combined working area of approximately 10,000 sq. ft. and includes 6 chemistry labs, of approximately 2,800 combined sq. ft., for synthesis. You will be expected to participate in applying for and maintaining external funding and eventually, under the mentorship of key senior investigators, be expected to acquire and sustain independent funding. Along with the establishment of the new labs and obtaining external funding, you will have the opportunity to hire, supervise, mentor, and provide training for staff as well as partner with external collaborators and contract research organizations.

About the School and Department: The Indiana University School of Medicine https://medicine.iu.edu/ is the largest medical school in the US and is annually ranked among the top medical schools in the US by US News & World Report. Please visit http://medicine.iupui.edu for additional information about the Department of Medicine.

About the Campus: To learn more about the Indiana University-Purdue University Indianapolis campus, please visit: http://www.iupui.edu/about/  

Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years. For additional information on life in Indy: https://faculty.medicine.iu.edu/relocation/  

As the nation’s largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana.

Required Qualifications:  PhD degree in science and four years of research experience

Preferred Qualifications:

  • PhD in organic chemistry, medicinal chemistry, chemical biology, or a closely related field.
  • Ability and desire to write competitive grants and obtain independent funding for independent research programs.
  • Strong communication skills, word processing, database searching, data entry, and data analysis (e.g. ChemDraw, Reaxys, SciFinder, Microsoft Office365, including Word, Excel, and PowerPoint.)
  • Expert in synthetic methodologies, retro-synthetic analysis, purification, and verification of chemical structure.
  • Experience in designing and synthesizing sets of compounds for structure-activity relationship (SAR) studies.
  • Experience optimizing drug-like properties of molecules (e.g. potency, solubility, metabolic stability, absorption, etc.)
  • Experience using databases and computational platforms for route design (Reaxys, SciFindern, IBM RoboRXN, etc.)
  • Experience with modeling and cheminformatics software packages (e.g., Schrödinger Maestro, MOE, ChemAxon, StarDrop, etc.).
  • Experience with workflow tools used in cheminformatics (e.g. Pipeline Pilot or KNIME).

The faculty rank for this scientist-track position is open (Assistant, Associate, Senior Research Professor) and will be determined based on the qualifications and experience of the successful candidate.

Department Contact for Questions Bridget Working bworking@iu.edu

To apply for this opportunity, visit: https://indiana.peopleadmin.com/postings/11130

IU is an equal opportunity employer committed to building a diverse learning environment and supporting the professional development of ethnic minorities, women, and people with disabilities. The IUSM strongly encourages applications from women and minorities. The IUSM provides concierge and dual career services to assist new faculty with their personal or family’s relocation needs.