Postdoctoral Scholar - Biomedical Engineering
The Medina group (https://sites.psu.edu/medinalabgroup/) at The Pennsylvania State University has two open positions for Postdoctoral Scholars. Projects span a range of programmatic themes, including protein and peptide biophysics, molecular self-assembly and drug delivery technologies.
Open projects include:
1. Investigating protein thermostability using surface-assembled molecular dispersants. This project will develop chemical coatings that improve the thermal stability of proteins, without compromising their structure or function. We seek to create novel bioformulation strategies with the potential to transform protein storage paradigms.
2. Exploring the biochemical landscape of fluorinated biologics. Scholars will examine how fluorine atoms can be introduced into amino and nucleic acids to access new ways to alter the folding, stability, oligomerization propensity and bioactivity of peptides, proteins and DNA.
3. Exploiting the fluorous effect to create adaptive matter. We have recently uncovered the ability of organofluorine molecules to direct protein and DNA assembly into supramolecular microdomains with unique structural, thermodynamic and biochemical properties. Scholars will leverage these findings to rationally design fluorous biopharmaceuticals, gene editing technologies and bioresponsive materials.
The position will be in the Biomedical Engineering (BME) Department and affiliated with the Huck Institutes of the Life Sciences (http://www.huck.psu.edu/) and Penn State Cancer Institute (https://cancer.psu.edu/). We offer a rich environment where faculty, postdocs, graduate students and undergraduate researchers regularly interact and collaborate. Scholars will have unrestricted access to our state-of-the-art core facilities to explore their emerging and interdisciplinary research interests.
Each position requires a Ph.D. by the time of appointment in Chemistry, Molecular Biology, Biomedical Engineering, or a related discipline. Preference will be given to candidates with expertise in fluorine chemistry, peptide synthesis, molecular self-assembly and biophysics. Additional expertise in molecular modeling is a plus. The duration of the appointment is for one year, with the possibility renewal depending on availability of funds.
Qualified candidates should apply online and include: a one-page cover letter detailing their research expertise, scientific interests and career goals, as well as a complete curriculum vitae with three professional references. For more information, please contact Dr. Scott Medina (shm126psu.edu).
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