The laboratory of Dr. Jessica Fortin at Purdue University (Fortin Drug Discovery Lab) has an opening for a Post Doc Research Associate in medicinal chemistry to synthesize small molecules and investigate their anti-fibrillary activity on hyperphosphorylated tau, a relevant target for Alzheimer’s Disease. The candidate will be involved in the hyperphosphorylated tau project using routine organic chemistry, purification techniques, ThS fluorescence assays, and additional biophysical assays (e.g. DLS, ITC). To learn more about the lab: https://vet.purdue.edu/discovery/fortin/. The Post Doc will be working on a project funded by a NIH R21 grant and have the opportunity to interact with the collaborators on the grant: Drs. Min-Hao Kuo (MSU), Edmund Ellsworth (MSU), and Scott Counts (MSU). For the chemistry portion of the project, Dr. Fortin consults also with Dr. Herman Sintim at the Purdue Institute for Drug Discovery.
Description of duties:
* Perform research and document project-specific experiments, e.g. synthesizing/purifying/characterizing small molecules and perform drug candidate screening.
* Prepare lab reagents.
* Lab organization, organize/update chemical inventory from commercial source and in-house library of molecules.
* Data compilation and analyses of biophysical and biological properties of molecules.
* Establish more advanced chemistry reactions for optimization of small molecules and assist in training chemistry lab members on basic chemical reactions.
* Compile and summarize experiment results for reports and publications.
Unit Specific Education/Experience/Skills:
Up to six months of related and progressively more responsible or expansive work experience in basic research techniques and knowledge of medicinal chemistry and organic chemistry; word processing, spreadsheet, database and/or desktop publishing software, presentation software, or an equivalent combination of education and experience.
* PhD in organic chemistry or medicinal chemistry
* Attention to detail and thoroughness in record keeping
* Demonstrated organizational skills
* Experience with organic chemical synthesis of small molecules with techniques of purification
* Experience with NMR spectroscopy
* Experience in drug screening, biophysics and molecular biology are advantageous but not required
* Demonstrated ability to work independently and in a team environment
* Willingness to learn new laboratory techniques and procedures
* Collaboration with other members in the lab is essential.
Equal Employment Opportunity Statement:
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.
Required Application Materials:
Cover letter - briefly summarize research experience, career goals, and how you could contribute to the research in the Fortin Drug Discovery Lab.
Names and contact information of three professional references
Please email the application materials to firstname.lastname@example.org. Application materials will be reviewed on Sept 22, 2021.
Description of End Date:
This is a position funded for two years from date of hire, with possible extension contingent upon funding renewal.