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Computational/Cheminformatics Toxicology Scientist

FMC Corporation
Newark, Delaware
Competitive Market Rate Based On Experience
Closing date
Dec 5, 2021
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Job Details


FMC Global Regulatory Sciences is looking for a highly-motivated individual to work in our Human Health Sciences Group at our Newark, Delaware, research facility. The Cheminformatics Scientist position requires broad knowledge of chemistry/biochemistry (i.e. organic chemistry, biochemistry, pharmacology or similar) with practical experience of pharmacokinetics, pharmacodynamics, toxicology, metabolism and quantitative structure-activity relationships.

This is an office-based position that utilizes experimental knowledge and regulatory know-how to support and advise internal multidisciplinary functions from early research and development through commercialization and defense of materials in the FMC agrochemical portfolio. This position will support internal scientists from aligned disciplines, such as toxicology, metabolism chemistry, residue analytical chemistry, and risk assessment to make informed decisions about overall risk and ability to register active ingredients and pesticide products.


  • Use computer models and predictive technology to determine quantitative structure-activity relationships (QSAR), complete chemical evaluations and predict hazard for untested chemicals (impurities, metabolites and degradation products of active ingredients) in support of registration approvals.
  • Partner with key internal scientists, registrations managers, or external technical experts worldwide to generate necessary data for developing QSAR models for active ingredient, metabolites, impurities, and degradation products.  
  • Employ QSAR models effectively utilizing appropriate software to generate summary reports to meet regulatory requirements and submission deadlines.
  • Review draft reports and provide comments to CROs that generate input data for the QSAR models to achieve accurate assessments and final reports.
  • Prepare dossier submissions in the area of toxicology/human health assessment in an appropriate format consistent with regulatory requirements according to agreed timeframes.
  • Respond appropriately to regulatory questions and requirements in the area of human health risk to support development, registration, re-registration, and label expansion for FMC products and innovative chemistry or technology.
  • Effectively manage numerous tasks/projects simultaneously.
  • Participate in industry task forces and/or Agency meetings to keep abreast of new developments in the area of QSAR. 
  • Attend professional meetings and scientific/technical training or workshops to maintain and improve technical skills. Publish or present scientific information at meetings and in journals. 

Required Education:

A Ph.D. degree in Computational Chemistry, Organic Chemistry, Medicinal Chemistry, Biochemistry, Pharmacology, Toxicology or equivalent discipline with minimum 5 years of relevant experience in agricultural, chemical or pharmaceutical industry, or Master’s degree in one of the noted disciplines with a minimum 10 years of relevant experience. 


  • Demonstrated experience and proficiency with DEREK, METEOR, MultiCASE, TOPCAT, OECD Toolbox or similar computer programs and database(s) to conduct QSAR evaluations and predict hazards for untested impurities and degradation products of active ingredients in support of technical active ingredients.
  • Experience with computer programming using open-source tools (including R, Python, JAVA or KNIME).
  • Familiarity with data mining / management as well as structure-based, machine learning, cheminformatics, and statistical approaches to assess toxicity.
  • Broad scientific knowledge in organic chemistry, natural products, biochemistry, pharmacology or similar chemistry discipline for agricultural or pharmaceutical products. 
  • Computer skills with data management experience with the ability to quickly learn and evaluate new software and modify or trouble-shoot existing QSAR tools.
  • Ability to critically evaluate complex scientific data in order to provide recommendations to key staff and management.
  • Strong interpersonal skills working effectively within a team environment - exchanging ideas with colleagues, sharing workload, and interacting with supervisors. Must be able to thrive in a global, customer service-oriented team with a high level of self-direction and motivation. 
  • Excellent and effective written and verbal communication skills. Technical writing capabilities for comprehensive scientific reports, hazard evaluations, and presenting chemistry to/for appropriate target audiences.
  • Strong commitment to and awareness of safety practices.  

Additional Beneficial Experience 

  • Familiarity with chemical metabolism, pharmacology and biochemically-based mechanisms of toxicity, such as mutagenicity and carcinogenicity.
  • Familiarity with open source QSAR platforms and graphical user interface (GUI) development.
  • Familiarity with broad classes of agricultural chemicals.
  • Experience and practical knowledge of global regulations and regulatory processes for human health risk assessments for agrochemicals using QSAR software.
  • Practical GLP laboratory experience and detailed working knowledge of study design and data requirements in the areas of QSAR predictions.
  • Experience of supporting biologicals also an advantage.
  • Registration knowledge for biocides, pharmaceutical, or specialty chemicals.
  • Experience communicating with non-science, business and registration customers and meeting their expectations.


Feeding the world, protecting health, and providing the conveniences of life. That is the mission of FMC. With our superior technology and strong partnerships with customers, FMC's people are finding solutions that are helping to change people's lives for the better. Today, FMC maintains leading positions in three chemical markets: Agricultural, Specialty, and Industrial. FMC Corporation is a global, diversified company serving the world for more than a century with innovative solutions, applications and quality products. FMC employees enjoy competitive compensation, a menu of work/life benefits and opportunities to expand their range of skills and further develop their career.

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