Process Chemistry Scientist

New York City, New York
Not disclosed
Closing date
Jun 26, 2022

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Field of specialization
Work Function
Job Type
Full time
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The Scientist/Senior Scientist is a member of the Preclinical Development team working to support discovery and the synthesis of API for IND-enabling and clinical studies. Candidates must be highly motivated with previous experience in scale-up of API, from discovery to the clinic, and managing external partners. While this is a lab-focused position, the right candidate can work remotely, depending on experience. Successful candidates must be able to work effectively both in a collaborative setting and independently, while possessing outstanding written, visual and oral communications skills.


  • Support medicinal chemistry by overcoming synthetic roadblocks to chemical intermediates and active pharmaceutical ingredients (API) and streamlining SAR
  • Design and perform experiments to enable new route design and development/implementation of phase appropriate and robust synthetic processes to successfully facilitate the delivery of preclinical and clinical API batches at CDMOs
  • Manage vendor / CDMO teams conducting scale-up activities to deliver API required for IND-enabling studies
  • Summarize and present experimental results to the project team to facilitate strategic planning, risk-assessment, and decision-making in a collaborative team environment


  • M.Sc. or higher degree in organic chemistry with 5+ years of drug discovery/development experience, with an emphasis on developing chemical processes
  • Familiarization with modern process chemistry techniques: crystallization development, route/step optimization, HPLC analysis and assay, process safety and impurity control
  • Experience managing external partners
  • Exceptional problem-solving skills and ability to quickly adapt and shift focus as needed
  • Excellent interpersonal, communication, and collaboration skills
  • Ability to multi-task in a fast-paced dynamic environment while demonstrating a calm and positive attitude and a superior work ethic

About Kallyope:

Kallyope is a new biotechnology company headquartered in New York City.  Founded by Richard Axel, Tom Maniatis, and Charles Zuker from Columbia University, Kallyope is focused on the identification of new therapeutic and nutritional opportunities involving the gut and gut-brain axis. The Company leverages the founders’ formidable expertise in molecular biology, neuroscience, and behavior to identify new approaches to human health. 

Kallyope is seeking creative, highly motivated individuals who are interested in working in a biotech environment that is scientifically stimulating, highly collaborative, and laser focused on translational biology.   The Company is creating an industry-leading platform employing cutting edge technologies including sequencing, genetics, circuit mapping, neural imaging and bioinformatics. By integrating and applying complementary tools and approaches to the understanding of gut and gut-brain biology, Kallyope aims to develop transformational therapeutics and consumer products to improve human health and nutrition.

The Company is headquartered in the Alexandria Center® for Life Sciences, a state-of-the-art, collaborative life science campus in the heart of Manhattan, with close proximity to New York City’s world-leading clinical and research institutions.  Kallyope has raised $252M in funding from several top-tier investors. The Company has assembled a leadership team and advisory group with a proven track record of success and strong expertise in drug discovery and translation. The founding scientific team is composed of highly creative and talented individuals with outstanding expertise in the Company’s core platform technologies.  For more information, see

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