Director of Compound Management & Cheminformatics

Director of Compound Management and Cheminformatics

CHDI, has a position open for an individual with compound management and cheminformatics experience. This position will have regular interactions within CHDI scientists and project managers as well with CRO collaborators. Major responsibility will be compound management form registration to dispatches as maintaining and extending Dotmatics, Pipeline Pilot, custom restoration software and Schrodinger Live Design. The individual will be based in either Princeton NJ or Los Angeles CA reporting to VP, Chemistry and Drug Discovery.   Job Responsibilities The successful candidate will interface with information scientists, computational chemists, medicinal chemists, protein crystallographers, and biologists and will be responsible for compound registration, compound dispatching, compound property profiling and filtering, uploading of chemical data, and general curation of the company’s internal databases. Candidate will be involved in developing and evaluating statistical, clustering, and partitioning models (QSAR, QSPR, CoMFA, etc.) and to use such models to understand structure activity relationships, chemical and biological profiles of compounds, and to aid with compound optimization and library design.  Other desirable activities are 3D-Pharmacophore development, database searching and protein-ligand docking and scoring. The ideal candidate will be involved in maintaining and extending Dotmatics, Schrodinger LiveDesign, Pipeline Pilot, and a custom small molecule registration software. Supporting these platforms requires to maintain and develop scripts in Python, R, SQL and Pipeline Pilot. Interacting with internal and external scientists at our CROs. Managing our compound repository at Evotec Toulouse inclusive of compound registration and dispatches across our CROs and academic collaborators.  

Qualification for Director of Compound Management and Cheminformatics

• The position requires a M.S./Ph.D. degree in chemistry /chemi-informatics or a related field and hands-on experience in cheminformatics support and compound management. Experience in compound registration and dispatching compounds. Experience working in a team in an industrial drug discovery setting and the ability to handle multiple projects will be an important asset. Knowledge of working with data housed in a relational-database system is required.  Knowledge in developing scripts for Python, Pipeline Pilot, and SQL. Strong communication and programming skills are required.

  About CHDI Foundation, Inc.

CHDI Foundation, Inc. is a privately funded, not-for-profit, biomedical research organization that is exclusively dedicated to rapidly discovering and developing therapies that slow the progression of Huntington’s disease (HD). Our scientists work closely with a network of more than 600 researchers in academic and industrial laboratories around the world in the pursuit of these novel therapies, providing strategic scientific direction to ensure that our common goals remain in focus. This helps bridge the translational gap that often exists between academic and industrial research pursuits and that adds costly delays to therapy development. In its role as a collaborative enabler, CHDI seeks to bring the right partners together to identify and address critical scientific issues and move drug candidates to clinical evaluation as rapidly as possible. Our activities extend from exploratory biology to the identification and validation of therapeutic targets, and from drug discovery and development to clinical studies and trials. More information about CHDI can be found at www.chdifoundation.org

About CHDI Management, Inc.

CHDI Management, Inc. was established in 2002 to provide administrative, management and grant making services to CHDI Foundation, Inc.