Organic Chemist

National Institutes of Health
Bethesda, Maryland
Salary is commensurate with research experience and accomplishments.
Closing date
Oct 22, 2022

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Field of specialization
Work Function
Laboratory, Research-Applied
Job Type
Full time
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Job Details

Position: Organic Chemist

National Heart, Lung, and Blood Institute

Division of Intramural Research

With nationwide responsibility for improving the health and well-being of all Americans, the Department of Health and Human Services oversees the biomedical research programs of the National Institutes of Health (NIH) and those of NIH’s research Institutes. The Division of Intramural Research (DIR) of the National Heart, Lung, and Blood Institute (NHLBI) is seeking an outstanding chemist to support the Chemistry and Synthesis Center (CSC). The CSC provides DIR researchers with targeted imaging probes that help accelerate cell based assays, in vivo imaging studies, and translational research leading to better disease diagnosis. The Center comprises a core synthesis facility dedicated to the preparation of imaging probes, a research component dedicated to the discovery of new imaging approaches and compositions, and early drug discovery compounds to collaborating scientists. The existing faculty is an outstanding group of internationally recognized biomedical researchers covering a wide range of basic and clinical research topics (please see complemented by the other research institutes within the DIR (please see

The NHLBI is looking for an experienced synthetic organic chemist to work within the Chemistry and Synthesis Center (CSC). Candidates must have a PhD in organic synthesis or medicinal chemistry.  Additional training in post-doctoral research is valued. The ideal candidate will have expertise in total synthesis of complex natural products, or synthetic method development as demonstrated by scientific publications.  Prior experience with medicinal chemistry is of interest.  Knowledge of modern synthetic techniques and expertise in common analytical methods are expected. 

The chemist will synthesize small molecules for diagnostic imaging applications, or early drug discovery efforts.  The focus of the research involves the synthesis of small molecules as new chemical tools for biologists and includes compounds for targeted protein degradation, and MRI, optical or PET imaging.  Experience with or knowledge of fluorescent dyes, chelators for radioactive metals, MRI agents and nanoparticles is beneficial. The work requires the ability to devise synthetic approaches to target molecules and propose alternative synthetic routes. The successful candidate has good communication skills and is able to work in a collaborative environment, within a service group.

Salary is commensurate with research experience and accomplishments. Candidates may be U.S. citizens or non-citizens who have, or are eligible to obtain, a valid employment authorization visa.

Applications from women, minorities and persons with disabilities are strongly encouraged. Applicants should send  their current curriculum vitae with complete bibliography emailed to:

Dr. Rolf Swenson, CSC Center Director, NHLBI


DHHS, NIH, and NHLBI are Equal Opportunity Employers.


This position is at the National Institute for Biomedical Imaging and Bioengineering. For more information, see

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