Synthetic Medicinal Chemist

Employer
Washington University School of Medicine
Location
Saint Louis, Missouri
Salary
Competitive and Negotiable
Closing date
Jan 2, 2023

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Job Details

Two exciting job opportunities are immediately open in the areas of synthetic medicinal chemistry and drug discovery. My lab has multiple long-term NIH funded infectious disease projects directed at chemical biology. medicinal chemistry and drug discovery. One current job opening involves the X-ray structure-based design and synthesis of small-molecule glycoside inhibitors as novel anti-virulence therapeutics targeting bacterial adhesins (lectins). The other exciting position is focused on the rational design, synthesis, and lead optimization of heterocyclic small molecule inhibitors of TgCDPK1 kinase as new drugs for the treatment of the parasitic disease Toxoplasmosis.

Requirements: Ph.D. in organic or medicinal chemistry (or B.S./M.S. level with 5+ years of experience) and a strong publication record. Expertise in synthetic organic and medicinal chemistry as well as the use of modern techniques and instrumentation for purification and structural characterization required. Ability to work independently, communicate data and results clearly coupled with strong analytical and problem-solving abilities are necessary. Experience with heterocyclic, peptide, and/or carbohydrate chemistry and a history of successfully working in a collaborative, multidisciplinary team environment is preferred. Knowledge and practice of structure-based drug design including use of computational docking and molecular modeling software experience is a plus.

Please submit applications enclosing a cover letter with copies of current curriculum vitae/resume and summary of research experience to: Dr. James W. Janetka, Washington University School of Medicine, 660 S. Euclid Ave., Box 8231, St. Louis, MO 63110, or email at janetkaj@wustl.edu.

Company

Washington University School of Medicine is a world leader in biochemical research and the training of young scientists. Members of the Department of Biochemistry and Molecular Biophysics, originally called the Department of Biological Chemistry, are dedicated to the investigation of the complex relationships that control biological processes. These processes, in turn, are defined by complex interactions between proteins, between proteins and nucleic acids (DNA and RNA) and between proteins or nucleic acids with small metabolites. A major focus of the department is to seek to understand these processes in a quantitative way based on understanding structural and dynamic aspects of macromolecular interactions. Investigators utilize experimental structural, thermodynamic and kinetic methods as well as computational approaches in their studies. The significance of delineating the quantitative structural basis of molecular and cellular events lies in providing the fundamental knowledge required for furthering our ability to make advances in medicine and improvements in the quality of life.

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