Summary The National Center for Advancing Translational Sciences (NCATS) is seeking a Senior Scientist with scientific, administrative, and leadership credentials who can lead a program to operationalize the use of biologically inspired, engineered assay platforms for therapeutics discovery and development. The program will advance platform technologies that include material and device design along with technologies to detect the biological events being studied.
Duties This position serves as a Senior Scientist directing the Precision Therapeutics and Translational Technologies (P3T) Program located within the Chemical Genomics Branch (CGB), Division of Pre-Clinical Innovation. The Director of the P3T Program would lead a team in utilizing multiple paradigms in lead discovery ranging from high throughput screening to fragment based methods to scaffold hopping and will direct staff in developing innovative strategies to pharmacologically modulate currently 'undruggable' cellular targets and pathways. They will lead the development of disease models that more faithfully replicate diseased cells and tissues using high-throughput capable 3D-cell cultures and organoid-based screening methodologies, with the application of spatially resolved single-cell transcriptomics. Using publicly available datasets, the individual would enable the discovery of multi-component gene modules (pathways) to shift the focus of the genetic-dependency paradigm from individual genes to multi-component pathways to develop novel drug-regimens for specific cancer subtypes. Using system-level approaches the Senior Scientist would lead the team in creating platforms capable using existing chemogenomics screening capabilities to test pre-defined therapy options for precision treatments.
Qualifications To qualify for a Senior Scientist position you must meet the following Education Requirements: have completed the requirements for a bachelor's (or graduate) degree in a biological science, agriculture, natural resource management, chemistry, or related disciplines appropriate to this position, from an accredited college or university;
have a combination of experience and education that includes courses comparable to a major in a biological science, agriculture, natural resource management, chemistry or related disciplines appropriate to this position, AND have appropriate experience or additional education that demonstrates similarly appropriate skills or abilities needed to perform the duties of this position.
In addition to meeting the education requirements, you must demonstrate in your resume service obtained in either the private or public sector, performing the following types of tasks: directing and managing a large and scientifically diverse research program; utilizing state-of-the-art methods in disease model development and characterization such as high throughput chemogenomics screening; leading a laboratory in creating and using innovative screening platforms, including screening for novel drug-drug combinations to tackle resistance in oncology and infectious diseases; designing and synthesizing bioactive small molecules and creating small molecule libraries to analyze biological pathways; conducting phenotypic drug screening, and identifying genetic predictors of drug sensitivity and/or drug resistance; utilizing multiple paradigms in lead drug candidate discovery ranging from high-throughput screening to fragment based methods to scaffold hopping; development of disease models that replicate diseased cells and tissues using high-throughput capable 3D-cell cultures and organoid-based screening methodologies with the application of spatially resolved single-cell transcriptomics.
Ideal Candidate Although not required, the ideal candidate will be an internationally recognized and highly accomplished researcher in preclinical drug development with the ability to exploit opportunities within a high-tech, collaborative and enabling environment at the interfaces of chemistry, biology, and medicine. The individual will have demonstrated strategic and tactical capability to utilize state of the art methods in disease model development and characterization, high throughput chemogenomics screening, medicinal chemistry/chemical biology, and therapeutic development. They must demonstrate the ability to plan and direct a broad and comprehensive program to expand on chemogenomic screening methods with integrative gene editing techniques. They will have established novel small molecule development methods focused on modulating underrepresented cellular targets and pathways. They will have achieved Clinical Laboratory Improvement Amendments (CLIA) certification for precision medicine labs. The ideal candidate will have extensive expertise with operationalizing the use of system-wide biomarker signatures for use as a stand-alone means to focus therapies for precision medicine approaches, including driving innovation in the discovery of novel drug combination regimens. They would have demonstrated leadership abilities with establishing collaborations with a broad range of internal and external stakeholders both domestically and internationally.
Salary and Benefits: The salary range is commensurate with experience and accomplishments. The current salary range for this position is $183,501 - $245,000. A full benefits package is available, including a retirement plan; health insurance, life insurance, and long-term care insurance; annual and sick leave; and Thrift Savings Plan (401K equivalent). The National Institutes of Health inspires public confidence in our science by maintaining high ethical principles. NIH employees are subject to Federal government-wide regulations and statutes as well as agency-specific regulations described at the NIH Ethics website: http://ethics.od.nih.gov
How to Apply: Please submit a cover letter describing your interest in the position including a career synopsis (1-3 pages); statement of research interests (1-2 pages); a current curriculum vitae and complete bibliography; and the names and contact information of five references to NCATSRecruitAC1511@nih.gov.
Please include in your CV a description of mentoring and outreach activities in which you have been involved, especially those involving women and persons from racial/ethnic or other groups that are underrepresented in biomedical research. Questions regarding the application process should be addressed to Carrie Watkins, firstname.lastname@example.org.
All information provided by candidates will remain confidential and will not be released outside the NCATS search process without a signed release from candidates. The NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities. DHHS and NIH are Equal Opportunity Employers.