Description
1. Synthetic Route Design & Process Development
Route Scouting & Design: Design, evaluate, and optimize synthetic routes for APIs and key intermediates, balancing efficiency, safety, scalability, and cost considerations.
Reaction Development: Develop and optimize chemical reactions, including reagent selection, solvent systems, catalysts, and reaction conditions to improve yield, purity, and robustness.
Process Understanding: Apply strong mechanistic understanding and scientific rationale to guide development decisions and troubleshoot complex synthetic challenges.
Literature & IP Review: Conduct thorough literature and patent reviews to identify viable synthetic approaches and ensure freedom to operate.
2. Scale-Up & Manufacturing Support
Technology Transfer: Support the transfer of synthetic processes from laboratory scale to pilot plant and manufacturing environments.
Scale-Up Execution: Collaborate with manufacturing teams to scale reactions safely and reproducibly, addressing process risks and variability.
Troubleshooting: Provide hands-on technical support during scale-up, validation, and routine manufacturing to resolve process deviations and performance issues.
Safety & Risk Assessment: Conduct reaction hazard assessments and contribute to safe process design and implementation.
3. Scientific Leadership & Continuous Improvement
Technical Mentorship: Provide scientific guidance and mentorship to junior chemists, fostering technical growth and best practices in the laboratory.
Innovation & Improvement: Identify opportunities to improve synthetic efficiency, sustainability, and process robustness across development programs.
Knowledge Sharing: Contribute to internal knowledge bases, best-practice documents, and continuous improvement initiatives within Process Chemistry.
Requirements
Education: PhD in Organic Chemistry or a closely related scientific discipline.
Experience: 0-5+ years of postdoctoral or industry experience in synthetic organic chemistry, process development, or pharmaceutical R&D.
Technical Expertise: Strong hands-on expertise in complex organic synthesis, reaction optimization, and impurity control for small-molecule APIs.
Scale-Up Experience: Demonstrated experience supporting scale-up and technology transfer to pilot or commercial manufacturing environments.
Communication: Excellent written and verbal communication skills, with the ability to clearly document work and communicate technical concepts to cross-functional teams and external stakeholders.